US panel backs first drug from DNA-altered animals

<http://www.reuters.com/article/rbssHealthcareNews/idUSN0931526820090109>http://www.reuters.com/article/rbssHealthcareNews/idUSN0931526820090109
 


Fri Jan 9, 2009 6:26pm EST

By Susan Heavey

ROCKVILLE, Md., Jan 9 (Reuters) - A U.S. advisory panel recommended 
approval of what would be the first drug made using genetically 
engineered animals on the U.S. market, saying it appeared safe and 
effective despite concerns heard from groups worried about the 
genetic tinkering.

The product, GTC Biotherapeutics Inc's (GTCB.O) experimental 
anticlotting therapy Atryn, is made using a human protein from female 
goats engineered to produce it in their milk. GTC is seeking approval 
to sell the intravenous therapy to prevent excessive blood clots in 
patients with an inherited clotting disorder.

Company data showed the drug was safe and effective, the majority of 
the Food and Drug Administration's 19-member panel said on Friday. 
The FDA will weigh the recommendation as it decides whether to 
approve the product. A decision is expected by Feb. 7.

"This will ... set a precedent for what will happen in the future," 
said Dr. Richard Colvin, the panel's consumer representative and a 
clinical assistant in medicine at Massachusetts General Hospital.

But some genetic-safety and animal advocates at the meeting expressed 
concern about the use of such so-called transgenic animals despite 
the drug's benefits, saying more information is needed from the 
agency about genetically engineered animals overall.

The FDA issued preliminary guidelines in September about how it would 
regulate animals whose DNA has been altered and called for public 
comment, but it has not yet issued final details.

Approving Atryn "would be a back door way to approve transgenic 
animals," said Jaydee Hanson, a policy analyst for the nonprofit 
group Center for Food Safety.

Between 60,000 and 600,000 people in the United States have the 
excessive clotting disorder, known as hereditary antithrombin 
deficiency, according to GTC.

Atryn is made from human protein produced in milk from genetically 
engineered goats bred using cells injected with human DNA, according 
to GTC. Females then express the human anti-clotting protein in their milk.

The drug is licensed to Ovation Pharmaceuticals Inc [OVAPH.UL] in the 
United States. (Editing by Tim Dobbyn)



<*}}}>< <http://www.holypostage.com/>Holy Postage <*}}}><
<*}}}><<http://www.halfthekingdom.org/>Half the Kingdom!<*}}}><

Prayer for Unborn Life:
O GOD OF LIFE AND LOVE, You have given us the gift to participate 
with You to bring new life into the world.  But, all too often, the 
mother's womb, which should be a nursery of life, becomes instead a 
place of it's destruction.

Help us to remove this evil and ensure respect for all life made in 
Your image and likeness, called to fulfill its promise on this earth,
and destined to find a home with you for all eternity.

We ask this through Jesus Christ, Our Lord, Our God, Our Savior, and Our ALL.
Amen.


<*}}}>< <http://www.holypostage.com/>Holy Postage <*}}}><
<*}}}><<http://www.halfthekingdom.org/>Half the Kingdom!<*}}}><

Prayer for Unborn Life:
O GOD OF LIFE AND LOVE, You have given us the gift to participate 
with You to bring new life into the world.  But, all too often, the 
mother's womb, which should be a nursery of life, becomes instead a 
place of it's destruction.

Help us to remove this evil and ensure respect for all life made in 
Your image and likeness, called to fulfill its promise on this earth,
and destined to find a home with you for all eternity.

We ask this through Jesus Christ, Our Lord, Our God, Our Savior, and Our ALL.
Amen.

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