February 28, 2009

Jennifer Lahl


Ovulation Induction Linked with Cancer Risk

http://thehumanfuture.blogspot.com/2009/02/ovulation-induction-linked-with-cancer.html

Last Updated: 2009-02-25 14:02:09 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Treatments used to induce ovulation 
appear to 
<http://www.cancerpage.com/news/article.asp?id=13150>increase the 
overall risk of cancer, the results of a study published in the 
American Journal of Epidemiology suggest.

"Ovulation-inducing drugs are widely used for ovarian follicle 
stimulation, either as independent therapies or during in vitro 
fertilization cycles," Dr. Ronit Calderon-Margalit, of 
Hadassah-Hebrew University, Jerusalem, Israel, and colleagues 
explain. "The scientific literature provides inconsistent information 
on the association between ovulation induction treatment and cancer incidence."

To investigate further, the researchers examined data from 15,030 
women enrolled in the Jerusalem Perinatal Study who gave birth 
between 1974 and 1976 and then participated in a postpartum survey. 
The women were linked with the Israel Cancer Registry to obtain 
information on the number of cancers diagnosed through 2004.

A total of 1,215 women developed cancer. The 567 women who received 
drug treatment to induce ovulation had a 36-percent increased risk of 
developing cancer at any site.

Treatment with ovulation-inducing drugs was not associated with 
ovarian cancer, but increased the risk of breast cancer by 42 
percent; uterine cancer risk by more than 3-fold, and the risk of 
non-Hodgkin lymphoma by about 2.5-fold.

Treatment with the ovulation-inducing drug clomiphene specifically 
was associated with 4.6-times the risk of uterine cancer and 
2.6-times the risk of malignant melanoma.

"The potential implications of this study relate firstly to the need 
of further research and better registries of fertility treatments," 
Calderon-Margalit commented to Reuters Health.

"I believe that fertility treatments will continue, but if our 
findings will be confirmed by others, women who are treated with 
clomiphene, and perhaps other ovulation induction agents, will need 
screening for uterine cancer," she added. Future research will 
potentially explain the role of hormones in the development of 
cancers such as malignant melanoma and non-Hodgkin lymphoma.
SOURCE: American Journal of Epidemiology, February 1, 2009.


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