Vitamin B12 Can Prevent Major Birth Defects

<http://www.newsmax.com/health/vitamin_B12_birth_defects/2009/03/02/187227.html?utm_medium=RSS>http://www.newsmax.com/health/vitamin_B12_birth_defects/2009/03/02/187227.html?utm_medium=RSS
 


Monday, March 2, 2009 9:19 AM

Before becoming pregnant, women need to get enough vitamin B12 in 
addition to folic acid to cut their risk of having a baby with a 
serious birth defect of the brain and spinal cord, researchers said on Monday.

Irish women with the lowest vitamin B12 levels were five times more 
likely to have a baby with a neural tube defect than those with the 
highest levels, the researchers wrote in the journal Pediatrics.

Neural tube defects can lead to lifelong disability or death. The two 
most common ones are spina bifida, in which the spinal cord and back 
bones do not form properly, and anencephaly, a fatal condition in 
which the brain and skull bones do not develop normally.

Dr. James Mills of the U.S. National Institutes of Health, one of the 
researchers, said the study showed that vitamin B12 deficiency was a 
risk factor for neural tube defects independent of folic acid, 
another B vitamin.

Many women now know of the importance of folic acid and there has 
been a drop in neural tube defects.

Mills said he hopes that awareness of the similar role of vitamin B12 
can reduce neural tube defects further.

Vitamin B12 is essential to maintain healthy nerve cells and red 
blood cells. It is found in meat, dairy products, eggs, fish, 
shellfish and fortified breakfast cereals. It also can be taken as an 
individual supplement or in a multivitamin.

"An absolutely critical point is that women have to consider this 
before they become pregnant because once they realize they are 
pregnant it's likely to be too late," Mills, a researcher in the 
NIH's National Institute of Child Health and Human Development, said 
in a telephone interview.

The developmental events involved in these birth defects occur in the 
first four weeks of pregnancy, Mills said.

Mills urged women who do not eat meat or dairy products to be 
particularly aware of the need to get enough vitamin B12.

He had similar advice for women with an intestinal disorder such as 
inflammatory bowel disease that may prevent them from absorbing 
sufficient amounts of the vitamin.

The study involved almost 1,200 women in Ireland who gave blood 
samples during early pregnancy, which were analyzed to determine 
vitamin B12 levels.

The women in the lowest 25 percent of vitamin B12 levels were five 
times more likely than those in the highest 25 percent to have had a 
baby with a neural tube defect.

The researchers suggested that women have vitamin B12 levels above 
300 nanograms per liter before getting pregnant.

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