Mental Health: It's Life, Not Depression

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Friday, March 13, 2009 by: Dr. Julian Whitaker, MD, citizen journalist
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Sharon's husband was diagnosed with cancer, and 
they were looking at months of chemo and 
radiation. She was worried, had trouble sleeping, 
and found it hard to stay positive and upbeat for 
her husband. When she mentioned this to her 
doctor, he prescribed an antidepressant.

Laura was exhausted after the birth of her second 
child. Unlike her first baby, this one was fussy 
and rarely slept more than two hours at a 
stretch. On bad days, Laura questioned her 
ability to cope. She talked her symptoms over 
with her doctor and was prescribed an antidepressant.

Elizabeth, a bright and outgoing college student, 
would often wake up during the night worrying 
about one thing or another. One night, she awoke 
in a full-blown panic attack, her heart pounding 
so hard that she was sure she was going to die. 
She visited the campus infirmary the next day and 
was given a prescription for an antidepressant.

Thirteen-year-old Matt had just changed schools 
and was having a hard time adjusting to his new 
surroundings. His parents took him to see a 
psychiatrist, who-you guessed it-gave him an antidepressant.

Without question, Sharon, Laura, Elizabeth, and 
Matt were going through some tough times. But we 
all go through rough patches-it's part of being 
human. So how in the world did we arrive at such 
a place where normal emotions and reactions to 
life's events warrant treatment with drugs?

Let Them Eat Prozac

According to David Healy, MD, professor at Wales' 
Cardiff University, we can blame it on the drug 
companies. Dr. Healy is a conventional 
psychiatrist, but his well-documented and vocal 
criticisms about the safety and overuse of Prozac 
and other selective serotonin reuptake inhibitor 
(SSRI) antidepressants set him apart from his colleagues.

In his book Let Them Eat Prozac: The Unhealthy 
Relationship Between the Pharmaceutical Industry 
and Depression, Dr. Healy describes Prozac as a 
drug in search of a disease. It was the first 
SSRI to hit the market back in 1988, and, thanks 
to aggressive marketing, sales of antidepressants 
quadrupled in just two years. As Prozac's 
popularity soared, it was joined by Paxil, Zoloft, Luvox, and others like them.

Then Pandora's Box of direct-to-consumer 
advertising opened. Before long, drug company 
propaganda had people believing that unhappiness, 
anxiety, shyness, stress, obsessive thoughts, 
PMS, "baby blues," and other normal emotional 
reactions are diseases that can-and should-be 
treated with a pill. Patients started asking 
their doctors for prescriptions, and sales went through the roof.

Depression took on a whole new meaning. No longer 
was it limited to major depression, a clinical 
diagnosis marked by extreme emotional pain and 
inability to function. Mild-to-moderate 
depression has become a catchall diagnosis that 
will be slapped on one in four Americans at some point in their lives.

Inventing Illness, Selling Drugs

Today, 4 percent of men and 10 percent of women 
in this country are taking antidepressants. The 
bulk of the prescriptions for these meds are 
written by primary care physicians, not 
psychiatrists, and most of these "depressed" 
patients receive no other treatment or follow-up. 
In fact, the drugs seem to be handed out 
indiscriminately. The Centers for Disease Control 
reported that, after nonsteroidal 
anti-inflammatory drugs (NSAIDs), antidepressants 
are the most frequently prescribed of all classes of drugs!

Dr. Healy describes this mess as "wholesale 
creation of depression on so extraordinary and 
unwarranted a scale as to raise grave questions 
about whether pharmaceutical and other health 
care companies are more wedded to making profits 
from health than contributing to it."

If this sounds familiar, it's because you've 
heard me harping on this concept of "inventing 
illness" for over 20 years. Most of the ballyhoo 
about high cholesterol, ADHD, fibromyalgia, 
gastroesophageal reflux disease, and even high 
blood sugar and blood pressure is fueled by 
market-driven campaigns designed to do one thing: sell more drugs.

But the antidepressant story may be the worst of 
them all. As I will show you, these drugs do not 
work, they have the potential of inflicting 
tremendous harm-and, worst of all, the drug 
companies have known this for decades.

Antidepressants Don't Work...

Earlier this year, researchers evaluated 
published and unpublished pre-approval clinical 
trials that compared SSRI drugs with placebos. 
They combined the results in a meta-analysis and 
came up with some disturbing findings. SSRI 
antidepressants work no better than placebo, and 
their benefits do not meet the criteria for clinical significance.

For patients with moderate depression, SSRIs were 
a complete bust. The differences in improvement 
between people with severe depression taking a 
drug and those on placebo were virtually 
nonexistent. The sole group in which the drugs 
outperformed the placebo consisted of the most 
severely depressed patients, but the researchers 
concluded that this small difference was probably 
due to "decreased responsiveness to placebo... 
rather than to increased responsiveness to 
medication." (The placebo response in these 
studies was very high. An average of 80 percent 
of study participants felt better taking sugar pills.)

...And They Kill People

In addition to being ineffective, SSRIs are 
dangerous. They cause sexual dysfunction, weight 
gain, emotional apathy, headaches, insomnia, and 
gastrointestinal (GI) upset, and they have been 
linked with GI and uterine bleeding. But their 
most alarming side effect is an increased risk of 
suicide, hostility, akathisia (extreme agitation), and violent behavior.

Thousands of suicides, senseless murders, and 
other random acts of violence have been committed 
by people who were taking SSRIs. Michael 
McDermott went to work with an AK-47-type rifle, 
a shotgun, and a semiautomatic pistol, and killed 
seven of his coworkers. Kip Kinkel murdered his 
parents then went to school where he killed two 
and wounded 22 of his fellow students. Kristine 
Cushing used a .38-caliber pistol to shoot and 
kill her two young daughters while they slept; 
she then shot and wounded herself. Seung-Hui Cho 
went on a murderous rampage that resulted in 33 deaths and dozens of injuries.

At greatest risk are our children. The 
instigators of virtually all of the tragic school 
murder/suicides in recent years were taking an 
antidepressant or other psychotropic drugs. The 
same goes for more personal family tragedies, 
such as uncharacteristic suicides, self-harm, and 
violent behaviors that rip families apart.

Last year, I met Mathy Downing, the mother of 
Candace Downing, a beautiful, exuberant 
12-year-old honor student who had been put on 
Zoloft for "generalized anxiety disorder." A few 
months later, Mathy found her daughter dead, 
hanging above her bed. Just an hour before, she'd 
been watching Animal Planet on TV with her father.

Authorities in Great Britain have openly opposed 
the use of antidepressants in young people. The 
FDA, on the other hand, has decided only to 
require a black box warning label stating that 
these drugs increase risk of suicidal behavior in 
children, adolescents, and young adults. Sales 
have fallen off a little but remain strong. This 
is yet another example of the failure of the FDA, 
blinded by their incestuous relationship with the 
pharmaceutical industry, to protect the public.

"Lies, Damned Lies, and Statistics"

You're probably wondering how in the world such 
awful drugs generate $16.9 billion annually in 
global sales. I'll tell you. It's because the 
companies that push these pills have made a 
concerted and successful effort to deceive physicians and patients.

A 2008 study, published in The New England 
Journal of Medicine, examined the results of 74 
drug company-sponsored clinical trials on 
antidepressants. It turns out that of the 38 
studies with positive outcomes, 37 were 
published. However, 33 of the 36 studies with 
negative outcomes were either not published or 
they were reported in a way that "conveyed a positive outcome."

The drug companies also knew about the deadly 
side effects of SSRIs. Internal Eli Lilly 
documents, which date back to 1988 and were part 
of a product liability suit filed against the 
company in 1994, show that the company was aware 
Prozac conferred a 12-fold greater risk of 
suicide attempts than other antidepressants. The 
document also stated that the drug was associated 
with hostile behavior and that it more than 
doubled the risk of psychotic depression. What 
did they do with this knowledge? Nothing.

In an editorial in the September 3, 2008, issue 
of JAMA, Marcia Angell, MD, had this to say about 
pharmaceutical company-sponsored research: 
"Physicians can no longer rely on the medical 
literature for valid and reliable information. 
This is the conclusion I reluctantly reached 
toward the end of my two decades as an editor of 
The New England Journal of Medicine, and it has 
been reinforced in subsequent years. Clinicians 
just do not know anymore how safe and effective 
prescription drugs really are, but these products 
are probably nowhere near as good as the published literature indicates."

Life Isn't Always Easy

Folks, drugs aren't the answer. Most of the 
people treated with antidepressants are simply 
dealing with emotional upheavals in their lives, 
such as divorces, layoffs, and other losses. It's 
normal to be "sad and gloomy; dejected; downcast" 
(the definition of depressed) every once in a 
while. But it isn't clinical depression (defined 
as "so severe as to be considered abnormal, 
either because of no obvious environmental 
causes, or because the reaction to unfortunate 
life circumstances is more intense or prolonged 
than would generally be expected").

Life isn't always pretty. Puberty is tough. Our 
hearts get broken. Marriage isn't all smooth 
sailing. Divorce happens. Teenagers drive you 
crazy. Work isn't necessarily fun. Financial 
difficulties crop up. People get sick. Loved ones 
die. But the reality is, we have to use whatever 
tools we have to pull ourselves together and work through it.

Faith, religion, meditation, friends, family, and 
counseling can help you weather grief, worry, 
change, and other aspects of the human condition. 
Regular exercise is an excellent mood lifter, and 
a diet containing minimal amounts of starches and 
sugar prevents drops in blood sugar levels that 
can affect mood. Correcting hormone imbalances, 
particularly those involving thyroid, adrenal, 
and sex hormones, also makes a big difference.

So does a good nutritional supplement program. 
Omega-3 fatty acid deficiencies are associated 
with depression, so take six to eight fish oil 
capsules daily. SAMe (200-400 mg) and St. John's 
wort (900 mg) are proven mood enhancers, and 
vitamin B12 (1,000 mcg), magnesium (500-1,000 
mg), and zinc (30-50 mg) are also helpful. All of 
these supplements should be taken daily in divided doses.

Postscript

I want to close with an update on the people I 
told you about in the opening of this story.

Sharon, who started taking Luvox after her 
husband got sick, is still taking it nine years 
later. The drug doesn't make her feel all that 
great, and she's gained weight and has zero 
libido-common side effects of these drugs. But 
like so many others, she's afraid she'll feel worse if she stops taking it.

Laura, the young mother with the fussy baby, 
decided not to fill her prescription. Within a 
few weeks, the baby started sleeping six hours a 
night, and she was able to get more rest. Today, she feels great.

Elizabeth stayed on Paxil for five years-a time 
of her life she describes as going through "like 
a zombie." After learning about the downside of 
antidepressants, she started taking 
multivitamins, fish oil, and other supplements 
while slowly weaning herself off the drug. She's 
recently married and couldn't be happier.

And 13-year-old Matt? He hanged himself in his 
closet one week after starting Paxil.

References
*Angell, M. Industry-sponsored clinical research: 
a broken system. JAMA. 2008 Sept 3; 300:1069-1071.
*Barber, C. The medicated Americans: 
antidepressant prescriptions on the rise. 
Scientific American Mind. 2008 Feb 27.
*Healy, D. Let Them Eat Prozac. The Unhealthy 
Relationship Between the Pharmaceutical Industry 
and Depression. New York, NY: New York University Press; 2004.
*Kirsch I, et al. Initial severity and 
antidepressant benefits: a meta-analysis of data 
submitted to the Food and Drug Administration. PLoS Medicine 2008 Feb;5(2):e45.
*Turner EH, et al. Selective publication of 
antidepressant trials and its influence on 
apparent efficacy. N Engl J Med. 2008 Jan 17;358(3):252-260

Reprinted from Dr. Julian Whitaker's Health & 
Healing with permission from Healthy Directions, 
LLC. For information on subscribing to this 
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