HOW SYSTEMIC ENZYMES WORK TO CURE DISEASES
http://www.newswithviews.com/Howenstine/james175.htm
PART 2 of 2



By Dr. James Howenstine, MD.
March 17, 2009
NewsWithViews.com

Fibromyalgia

Fibromyalgia (FM) afflicts approximately 6 
million persons in the USA, predominately women 
in the 20-40 age bracket. FM is characterized by 
severe muscle pain, tenderness in 18 points where 
muscle and tendons merge, fatigue, headaches(50%), and severely impaired sleep.

This common condition afflicts nine times more 
women than men. These persons are troubled by 
severe unrelenting pain in areas where tendons 
join bone. Estrogen causes the deposition of 
fibrin, which can lead to impaired circulation 
with sludgy blood flow in the areas of fibrin 
accumulation. Hyperestrogenemia is common in our modern world.

The etiology of fibromyalgia is complex and not 
completely understood at this time. A multitude 
of infectious organisms have been found using 
high –resolution microscopy. The list of 
infectious pathogens identified in patients with 
fibromyalgia includes mycoplasma, anerobic 
bacteria, several types of fungi, and borrelia 
burgdorfi (Bb). The fungi appear to play an 
important role in causing endocrine dysfunction, 
presumably by the mechanism of releasing 
neurotoxic substances, into the bloodstream, 
which disrupt the normal function of the 
hypothalamus producing hypothyroidism and hypo-adrenal function.

Several patients with fibromyalgia have recovered 
when taking the Japanese enzyme nattokinase made 
from fermented soybeans. This improvement may 
have occurred because the enzymes are able to 
reverse the adverse effects of fibrin production 
and thus improve the circulation of blood into 
fibrotic areas. Other enzyme products (Wobenzyme, 
Vitalzyme, Lumrokinase) might also be valuable by the same mechanism.

Systemic Enzymes in Kidney Diseases

Acute and chronic glomerulonephritis are common 
kidney diseases. The patient with acute nephritis 
often has high blood pressure, swelling of the 
extremities, and blood and protein in the urine. 
This disease is considered frequently to be the 
result of an allergic reaction to the presence of 
streptococcal or other bacterial organisms in the 
body. Circulating immune antigen antibody 
complexes are common, and if the disease does not 
soon spontaneously resolve, scarring and fibrin 
deposits in the kidney’s urine forming units (glomeruli) are found.

Chronic damage to the kidney in time may lead to 
uremia, dialysis, and kidney transplantation. The 
presence of fibrin deposits, scarring of the 
kidney and circulating immune complexes makes a 
course of systemic enzyme therapy a good choice 
for these patients. This therapy is safe and has 
good potential to be beneficial.

Other kidney diseases that could also be helped 
by systemic enzymes include Goodpasture’s 
syndrome, Henoch-Schoenlein purpura, Mixed 
cryoglobulinemia, IGA nephropathy, periarteritis 
nodosa, Wegener’s granulomatosis, hemolytic 
uremic syndrome, hypersensitivity vasculitis, 
interstitial nephritis (drugs may cause 
this---antibiotics like gentamycin, vancomycin, 
amphotericin, etc., phenacetin, non-steroidal 
anti-inflammatory agents like naprosyn and 
indocin, and many chemotherapy drugs, ­or 
infection such as pyelonephritis).The pathology 
of swelling, inflammation and scarring(fibrosis) 
in all these conditions could be helped by systemic enzymes.

Use of Enzymes in Trauma

Serious injuries are usually followed by massive 
swelling and considerable pain. Immediate therapy 
with enzymes can dramatically shorten the 
disability and quickly resolve the pain. The key 
to this therapy is to take enough enzyme 
immediately as the battle is being lost when 
swelling and pain appear. Rehabilitation and 
recovery will be delayed. It is far more 
effective to use too much enzymes early than to 
have to frequently raise the enzyme dose because 
pain and swelling is spreading.

Lowering the enzyme dose is simple. This may call 
for using 15 to 20 capsules of systemic enzymes 
three times daily for injuries such as severe 
auto accidents with multiple fractures, 
dislocated hips or shoulders and following knee 
and hip replacements. Most likely the recovery 
period from joint replacement surgery could be 
significantly shortened if orthopedic surgeons 
used systemic enzymes. Patients taking enzyme 
therapy should stop this therapy 24-36 hours 
prior to elective surgery and resume the therapy 
24-36 hours after the operation. Taking enzymes 
during the immediate post-operative period could 
prevent the normal occlusion by fibrin in small 
blood vessel lacerations, which might produce 
oozing of blood with anemia postoperatively. 
German surgeons have effectively used enzymes in 
surgical patients for many years. Remember it is 
more effective to decrease the dosage when things 
are going well than to increase the dose when 
pain and swelling have gained the upper hand. 
Large doses of enzymes do not cause side effects.

My personal experience made me a believer in 
enzyme therapy. One of my molars needed a root 
canal, which I knew was dangerous in my diabetic 
state as it always creates an abscess in the root 
canal tooth which can never be sterilized. The 
extraction of the molar tooth was quite difficult 
as it required continuous effort by 2 dentists 
for 90 minutes. One of them later admitted it was 
one of the most difficult extractions he had ever 
performed. Within an hour I began taking 900 mg 
of bromelain three times daily (large dose). 
Neither pain or swelling appeared which surprised the dentist.

Enzymes and Estrogen Excess States (Fibrocystic 
Breasts, Fibroids of the Uterus, Endometriosis, 
Polycystic Ovaries, Benign Prostatic Hypertrophy, 
Cancers of Breast, Prostate, Uterus, Ovary).

Estrogens are able to produce fibrosis, and this 
capability leads to these painful disorders.

Several factors are producing the estrogen excess 
status that is widespread in the developed world:

• Breakdown of petrochemicals, pesticides, 
herbicides, plastics, sodium lauryl sulphate from 
cosmetics, propylene glycol, vehicle exhaust, and 
other agents into estrogenic substances in the human body.
• Extensive use of estrogenic hormones to 
expedite growth of cattle and chicken.
• Use of powerful pharmaceutical 
estrogens(Premarin) and oral contraceptive pills 
that magnify the existing estrogen excess in the female body.
• Misuse of estrogens in therapy as a sole agent 
instead of combining natural estrogen with safe 
natural progesterone, which nullifies the adverse 
effects of estrogen alone therapy.
• Diets high in sugar and dairy products, and low 
in fiber result in recycling estrogen into the 
body instead of elimination in the stools which 
occurs on high dairy diets. These diets also 
interfere with proper production of progesterone 
by the corpus luteum of the ovary.

Because of this state of estrogen excess, 
fibrosis, and painful cysts appear in breast 
tissue(fibrocystic disease of the breast). Many 
women cease ovulation 10 or more years before 
menopause due to this estrogen excess state. 
These women are thus unable to benefit from the 
estrogen ameliorating effects of progesterone 
production by the corpus luteum. The heavy 
intractable bleeding they experience often leads 
to hysterectomy. Existing fibroids in the uterus 
tend to appear and steadily enlarge under the 
stimulation of excessive amounts of estrogen.

Many women suffer from endometriosis, which seems 
to be produced by retrograde flow of blood into 
the peritoneal cavity at the time of 
menstruation. This fluid entering the peritoneal 
cavity contains blood and shed endometrial cells. 
A profound inflammatory reaction appears which 
often results in severe pain. Recurring episodes 
of this problem leads to “chocolate cysts” and 
scarring at the site of these peritoneal 
deposits. An unfortunate result of endometriosis 
is scarring of the fallopian tubes and sterility. 
The patient with endometriosis might need 5 or 
more capsules of enzymes three times daily until 
their pain disappears. Some women can ascertain 
when menstruation is imminent. These women could 
possibly be helped by starting enzymes before 
they notice the onset of menstrual pain.

Enzyme therapy can stop the development and 
enlargement of existing uterine fibroids. 
Patients with fibrocystic breast disease and 
enlarging fibroids should stay on enough enzyme 
therapy to prevent symptoms. Whether high doses 
of enzyme therapy over prolonged periods of time 
could completely dissolve large fibroids is not 
known, but it might well do so and appears to be worth a trial.

Another worthwhile approach to estrogen excess 
uses enzymes (DeAromatase[1]) which effectively 
corrects this problem by blocking the actions of 
the enzymes aromatase and 5 alpha reductase so 
that estradiol, testosterone and progesterone 
levels return to normal. Without this enzyme 
therapy androstenedione and testosterone are 
steadily converted into estrogen (estradiol). 
This raises already elevated levels of estradiol 
and diminishes already low levels of 
testosterone. To make matters even worse the 
enzyme 5 alpha reductase at the same time is 
converting testosterone into di-hydrotestosterone 
the substance believed to be responsible for some prostate gland enlargement.
When DeAromatase therapy comes on the scene 
progesterone begins to inhibit the action on 5 
alpha reductase causing rising testosterone 
levels and reducing the amount of estrogen formed.
Both testosterone and progesterone promote the 
p53 gene leading to normal healthy cell death 
(apoptosis) while estradiol promotes the Bel 2 
oncogene which blocks normal apoptosis (cellular death) and causes cancer.

Arteriosclerosis and Enzyme Therapy

One of the potentially most useful areas for 
enzymes is in stopping the progression, and 
hopefully promoting regression of 
arteriosclerotic plaques. Excessive clotting 
caused by infectious inflammatory reactions in 
the body is now believed to play an important 
role in the causation of arteriosclerosis. This 
can be reversed by the fibrin lysis occurring 
during enzyme therapy. Three cases illustrating 
clear improvement in arteriosclerotic symptoms 
after enzyme therapy are presented later in this article.

Keloids

Some patients develop thick unsightly 
scars(keloida) after surgery or injuries. Taking 
systemic enzymes following the surgery can 
prevent this excessive scar formation. 
Knowledgeable plastic surgeons use enzymes to 
minimize scar formation after surgery.

Case Reports

Case 1 A patient with a hip defect had 
considerable pain and difficulty walking. After 
starting serrapeptase he became completely pain 
free and walked in a normal fashion for the first time in years.

Case 2 A 34-year old male had a bad family 
history for vascular disease(three grandparents 
died of vascular disease at 56. 56, and 63 years 
of age, and his mother died of a heart attack at 
age 62). This patient took a prolonged course of 
intravenous chelation along with measures to 
correct arterial disease (high dosage vitamin C). 
He then had an ultrasound study of his carotid 
arteries , which revealed 12% narrowing of the 
right carotid artery and 14% narrowing of the 
left carotid artery. The site where the right 
carotid artery bifurcates into two arteries had a 
24% narrowing. He increased his vitamin C dosage 
to 10-12 grams daily, started taking 1.5 grams of 
lysine three times daily, and also took folic 
acid, B12 sublingually, twice daily, B6, and 
trimethylglycine. Serrapeptase 10 mg twice daily 
was begun. A repeat carotid artery study in 18 
months disclosed complete resolution of all 
plaques in the carotid arteries. Vitamin K2 45 
mcg. daily which removes calcium from arteries 
and moves it into bones would probably also have been a worthwhile therapy.

Case 3 In 1945, a six year old child and a friend 
fell into a pocket of radioactivity (about 
650,000 millicuries of Iodine 131 exposure) while 
playing a game. He immediately noticed burning in 
his lungs and trouble breathing. His friend died 
within a few months. And the girl who pulled him 
out of the hole died of the effects of 
radioactivity at age 35. He developed severe 
dyspnea with any exertion along with wheezing and 
scarring of his lungs and other organs.

At age 63, a knowledgeable physician urged him to 
take Vitalzym as, “It will dissolve the scar 
tissue.” His pulmonary function improved by 25% 
and he can now climb two flights of stairs without difficulty.

Case 4 A man with severe angina and claudication 
was not improved by laser therapy, robotic 
therapy, or endarterectomies of his coronary 
arteries. Therapy with ozone saunas and calcium 
EDTA chelation relieved his symptoms, but with 
exertion he still had problems. After a few days 
of Vitazlym, along with ozone saunas and 
chelation he was able to resume hunting. fishing, 
and hiking without any pain in his chest or legs.

Case 5 A man with angina at rest and claudication 
after walking 15 feet improved with calcium EDTA 
and ozone saunas. Within 2 days on Vitalzym he 
was able to walk to the grocery store without 
stopping or having either chest or leg pain.

Case 6 This woman had temporo-mandibular joint 
pain for several years with no response to laser 
surgery surgery, physical therapy, or 
acupuncture. Sleeping and eating were impaired 
due to pain. After two months of Vitalzym, she was pain free and much improved.

Case 7 This mother had her 18 month old son do a 
back flip onto her nose and the back of his head. 
smashed her nose. She was in severe pain with 
immediate swelling of her nose, cheeks, and eyes. 
She placed an ice pack on her face and took 20 
Vitalzym. The swelling began to disappear and the 
pain was nearly gone by the following morning. 
After 10 more Vitalzym capsules the next morning, 
the pain and swelling disappeared.

Hospital Formularies and Systemic Enzymes

Because systemic enzyme therapy was developed in 
Europe and the Far East, most US physicians are 
certainly unfamiliar with it. This means that 
patients landing in hospitals with some of these 
previously discussed problems may find themselves 
in an institution that does not stock systemic 
enzymes. Hospital formularies lean heavily toward 
pharmaceutical drugs, so the systemic enzymes may 
not be in the formulary unless unless the 
hospital is staffed by some knowledgeable plastic 
surgeons. Furthermore, hospital formularies do 
not like to stock a product that will be used by 
only one patient as unused portions of the 
product may expire. Even without the availability 
of enzymes in the formulary, some hospitals will 
permit patients to take outside therapy if the 
attending physician gives his or her approval.

More Research Needed

In reviewing the available literature about 
enzyme therapy, it is apparent that not all 
patients improve. Most studies show 75-80% of 
patients clearly improve. This raises a very 
important question. Would higher doses over a 
longer time frame have benefited those patients 
who failed to respond to the initial enzyme dosage?

The safety of systemic enzymes in high dosages 
means that we cannot be certain systemic enzymes 
would not help a patient until high doses have 
been tried over longer periods of time. It 
appears to me that this is particularly relevant 
in diseases like sarcoidosis, pulmonary fibrosis, 
scleroderma and uterine fibroids where there is 
such extensive scarring it would not be 
reasonable to expect prompt resolution. There is 
a possibility that severe scarring may not be 
reversible, but this needs to be proven as 
reversal of scarring in these serious health 
problems could be of immense value to the afflicted patients.

Practical Aspects of Enzyme Therapy

Tylenol(acetaminophen) is a very dangerous drug 
that, in my opinion, should never have been 
released. This drug is nearly universally found 
in US homes. Acetaminophen accelerates aging and 
can cause death from acute necrosis of the liver 
in young healthy persons who use this drug 
because of an acute viral infection. None of us 
needs speeding up of the aging process. Enzymes 
are far safer than this therapy for pain.

Having Lumbrokinase, Nattokinase, Wobenzyme, 
Bromelain or Vitazym+ in your home provides a 
therapy well qualified to alleviate a wide 
variety of painful disorders without any danger 
.to the user. The usage of enzyme therapy should 
increase as more health care practitioners learn 
about this exciting therapy. Vitalzym + and 
DeAromatase are available from 
<http://www.mynaturalhealthteam.com/>www.mynaturalhealthteam.com 
Phone 1-800-416-2806. For part one click below.

Click here for part -----> <james174.htm>1,

Footnotes:

1- Howenstine, J. 
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Physicians Guide To Natural Health Products That Work, or call 1-800-416-2806

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