Folic acid before conception may boost birth weight: Study

<http://www.nutraingredients.com/Research/Folic-acid-before-conception-may-boost-birth-weight-Study>http://www.nutraingredients.com/Research/Folic-acid-before-conception-may-boost-birth-weight-Study
 



By Stephen Daniells, 03-Apr-2009



Supplements of folic acid before conception may increase the birth of 
the baby by over 60 grams, according to a new study from the Netherlands.

Starting folic acid supplementation before falling pregnant was also 
associated with a 57 per cent reduction in the risk of low birth 
weight, and a 60 per cent reduction in the risk of a baby that was 
small for gestational age (SGA), according to findings published 
online ahead of print in the British Journal of Nutrition.

The results add weight to recommendations of a daily dose of 400 
micrograms for women of childbearing age, starting before conception.

Folic acid and NTDs

Currently, supplementation with folate and folic acid - the 
synthetic, bioavailable form of folate - is recommended to all women 
of child-bearing age since most neural tube defects (NTDs), including 
spina bifida and anencephaly, occur within the first 22 to 28 days of 
pregnancy, when the mother-to-be is not aware she is even pregnant.

Folic acid supplements after this time are too late to prevent neural 
tube defects and therefore fail to benefit women with unplanned 
pregnancies - more than half of all pregnancies in the US.

This connection between folate deficiency in early pregnancy and an 
increased risk of NTDs led to the 1998 introduction of public health 
measures in the US and Canada, where all grain products are fortified 
with folic acid.

While preliminary evidence indicates that the measure is having an 
effect with a reported 15 to 50 per cent reduction in NTD incidence, 
parallel measures in European countries, including the UK and 
Ireland, are still on the table.

Folic acid and birth weight

The Dutch researchers, led by Sarah Timmermans from Erasmus MC, 
analysed data on 6,353 pregnancies and considered the effects of 
folic acid supplementation (400 to 500 micrograms per day) before, 
during, and after conception on the birth weight of the infants.

The Generation R Study found that folic acid supplementation before 
conception was linked with heavier babies, and heavier placentas (13 
grams more), compared to the infants of women who did not take any 
folic acid supplements.

Benefits were recorded for women who started the folic acid 
supplements after having their pregnancy confirmed, with an 
association noted for a 39 per cent reduction in the risk of low birth weight.

Starting folic acid supplementation before falling pregnant was 
associated with reductions of over 50 per cent in the risks of low 
birth weight and small for gestational age (SGA).

"In conclusion, periconception folic acid supplementation is 
associated with increased foetal growth resulting in higher placental 
and birth weight, and decreased risks of low birth weight and SGA," 
concluded Timmermans and her co-workers.

Source: British Journal of Nutrition
Published online ahead of print 30 March 2009, doi:10.1017/S0007114509288994

"Periconception folic acid supplementation, fetal growth and the 
risks of low birth weight and preterm birth: the Generation R Study"
Authors: S. Timmermans, V.W.V. Jaddoe, A. Hofman, R.P.M. 
Steegers-Theunissen, E.A.P. Steegers

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