Antioxidant in Berries Stops Wrinkles

<http://www.naturalnews.com/026124.html>http://www.naturalnews.com/026124.html

Friday, April 24, 2009 by: Sherry Baker, Health Sciences Editor
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(NaturalNews) Data is mounting that phytochemicals found in a host of 
berries and other fruits can enhance health from the inside. Now 
comes research just presented at the Experimental Biology 2009 
meeting being held in New Orleans that a specific type of antioxidant 
phytochemical called ellagic acid holds the promise of enhancing our 
bodies on the outside, too. In fact, it may hold the key to 
successfully slowing down or even stopping skin aging.

Researchers in the laboratory of Dr. Young-Hee Kang at Hallym 
University in the Republic of Korea have found topical application of 
ellagic acid markedly prevents the two major causes of 
<http://www.naturalnews.com/wrinkles.html>wrinkles and aged-looking 
skin -- the destruction of 
<http://www.naturalnews.com/collagen.html>collagen and inflammation. 
Their findings are based on studies in human skin cells as well as on 
experiments with mice exposed to UV-B light that mimics the sun's 
skin-damaging ultraviolet radioactive rays.

Ellagic acid is found in many 
<http://www.naturalnews.com/fruits.html>fruits, vegetables and nuts 
but it is especially abundant in raspberries, strawberries, 
cranberries and pomegranates. Previous studies have suggested it has 
a photoprotective effect on the skin so the Korean scientists decided 
to try to find out the exact mechanism. They discovered that in human 
skin cells, ellagic acid worked to protect against UV damage by 
blocking production of matrix metalloproteinase (MMP), enzymes that 
break down collagen in damaged skin cells. It also reduced the 
expression of a molecule known as ICAM that is involved in 
inflammatory reactions.

For their animal study, the researchers used 12 hairless mice 
genetically bred to be used in dermatology studies because of the 
physiological similarities of their skin to that of human skin. For 
about two months, the rodents were exposed to increasing ultraviolet 
radiation, beginning at a level that would normally cause redness or 
sunburn and increasing to an amount that would have definitely caused 
damage to a person's skin. Half the mice were given topical 
applications of ellagic acid but the other half didn't receive the 
<http://www.naturalnews.com/antioxidant.html>antioxidant skin coating.

The results? The mice exposed to UV radiation without the ellagic 
treatment developed wrinkles and thickening of the skin but the group 
that received a topical dose of ellagic acid showed reduced wrinkle 
formation. What's more, the ellagic acid tamed the inflammation 
response, kept collagen from degrading and prevented the skin from 
thickening. In a statement for media, the researchers concluded these 
results show that ellagic acid works to prevent wrinkle formation and 
photo-aging caused by UV destruction of collagen and inflammation.

There's more good news about ellagic acid, too. Scientists from the 
University of Louisville and Fox Chase Cancer Center published 
research recently in the International Journal of Molecular Science 
which strongly suggests ellagic acid can reduce damage to 
<http://www.naturalnews.com/DNA.html>DNA and, in fact, may help 
repair faulty DNA.

For more information:
<http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2635667>http://www.pubmedcentral.nih.gov/ar...
http://www.eurekalert.org/pub_relea...

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