Postdoctoral Position in Structural Biology of Cell-Matrix Adhesion

We are currently recruiting for a 3-year postdoctoral position in the field of 
Structural Biology of Cell-Matrix Adhesion at the Biochemistry and Cell Biology 
department of Liverpool University, UK. This position is funded by the BBSRC 
and offers a unique opportunity to contribute to cutting-edge research in the 
laboratory of Dr. Igor Barsukov.

As a successful candidate, you will have a strong background and expertise in 
either protein NMR spectroscopy or X-ray crystallography. Your primary focus 
will be on studying the structure and function of protein complexes involved in 
the formation of cell-matrix fibrillar adhesions, which play a crucial role in 
tissue formation, integrity, and regeneration. Recent research in our 
laboratory has highlighted the regulatory role of the adaptor protein tensin in 
fibrillar adhesions, particularly through its interactions with integrins and 
other proteins within the adhesion complexes. However, the precise mechanisms 
underlying this regulation, particularly the ability of tensin to form 
molecular condensates through phase separation, are not fully understood. In 
this position, you will utilize a wide range of biophysical techniques and 
advanced protein modifications to investigate the molecular details of tensin 
condensation and its interaction with integrin and other adhesion proteins.

Our department offers a supportive and technology-rich research environment for 
structural biology and biochemistry. This includes access to state-of-the-art 
facilities such as a High-Field NMR facility equipped with 600, 700, and 800 
MHz spectrometers with high-sensitivity cryo probes. We also have a Barkla 
X-ray crystallography facility with regular access to powerful synchrotron 
radiation facilities, as well as a protein analysis facility with advanced 
instruments for studying protein interactions.

To be considered for this position, you should hold a PhD degree in Biological 
Sciences or Chemistry. The post is available for a duration of 3 years. For 
more information, please contact Dr. Igor Barsukov at i...@liverpool.ac.uk.

To apply for this position and for more detailed information, please visit 
http://tinyurl.com/5e35csak. The closing date for applications is 15-Feb-2024



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