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<snip>
> 2. I'm looking for examples where proteins of some size, at least 100
> amino acids, have sequence identity of ~30% but do not have similar
> folds. Again, I'm having difficulties finding such and would appreciate
> any examples anyone can provide. (Wasn't there a contest or something
> where investigators were challenged to introduce the minimal sequence
> change that generated a 'different' structure?).
</snip>
For a somewhat related example of two 4-alpha-helical bundles sharing 98%
sequence identity but having different topologies have a look at
http://dx.doi.org/10.1016/S0969-2126(99)80081-1
The catch here is that the protein is not monomeric (it is a homodimer).
Nicholas
--
Dr Nicholas M. Glykos, Department of Molecular
Biology and Genetics, Democritus University of Thrace,
Dimitras 19, 68100 Alexandroupolis, GREECE, Fax ++302551030613
Tel ++302551030620 (77620), http://www.mbg.duth.gr/~glykos/
