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1) looks like its been answered many times
for 2), I recommend you "google" for "Paracelsus challenge". As I
recall, this was a cash prize offered by Rose and Creamer in (Proteins
19:1–3, 1994) to anyone who can find/make two proteins that have not
less than 50% identity, but different structures. There are several
examples out there of protein pairs that "meet" the challenge by
"cheating" in varous ways. I'm not sure if the prize was ever awarded,
but there were certainly a lot of interesting efforts to meet the criteria.
-James Holton
MAD Scientist
Yoder, Marilyn wrote:
My 'googling' skills are failing me and thought perhaps someone here
could point me in the right direction.
I have two questions.
1. It is often stated that with ~30% sequence identity, protein folds
will likely be similar. I can't find a reference to this
'rule-of-thumb'. I suspect there has been a systematic study showing
this to be the case, but I can't put my finger on it.
2. I'm looking for examples where proteins of some size, at least 100
amino acids, have sequence identity of ~30% but do not have similar
folds. Again, I'm having difficulties finding such and would
appreciate any examples anyone can provide. (Wasn't there a contest or
something where investigators were challenged to introduce the minimal
sequence change that generated a 'different' structure?).
Many thanks,
Marilyn Yoder
Marilyn D. Yoder
Division of Cell Biology and Biophysics
University of Missouri-Kansas City
5007 Rockhill Rd.
Kansas City, MO 64110-2499
phone: 816-235-1986
fax: 816-235-1503
