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2 Post-doc and 1
PhD-student positions available in Piet
Gros’ protein crystallography lab and Hans Gerritsen’s
molecular biophysics lab; Faculty of Science, Utrecht University, The
Netherlands. Job description Structural Biology and
Biophysics of the Complement Immune System The selected candidates will
work in a small team focused on understanding the immune response in blood
plasma by activating the complement system. Unregulated activity of the
complement system is associated with a wide range of auto-immune disorders. It
is our goal to understand the molecular principles that underlie complement
activation on cellular surfaces. The post-docs in this project will focus on reconstituting
complement activation using recombinant proteins and study complex association,
activity and dissociation by biochemical and biophysical (single molecule
fluorescence) techniques. One post-doc will focus on single-molecule
fluorescence and one will focus on molecular biology and the biochemistry of
reconstitution. The PhD student will focus on crystal structure determinations of
the key complexes in complement activation. The groups are well equipped and
experienced in mammalian protein _expression_ and protein crystallography (Gros);
and fluorescence microscopy (Gerritsen). The groups are part of the Key papers from our groups
include: Janssen et al. Nature 437, 505-511 (2005); Oomen et al. EMBO J. 23,
1257-1266 (2004); Huizinga et al. Science 297, 1176-1179 (2002); and Sark et al. Single
Molecules 1, 291-298 (2000);
Frederix et al. Applied Spectroscopy 55(8), 1005-1012 (2001). Qualifications All candidates must have a
strong background in molecular and/or structural biology and/or molecular
biophysics. For the PhD position the ideal candidate is an enthusiastic and
highly motivated researcher who recently graduated (MSc
in chemistry, biology or related field). Good English language skills are prerequisites. Candidates for the Post-doc position should have a Ph.D.
degree in chemistry, physics or biology. Publications in scientific journals
are considered as advantages. Good English language skills are prerequisites. Further details http://www.crystal.chem.uu.nl/group-gros/ http://www1.phys.uu.nl/wwwmbf/ Terms of employment PhD position
We offer a
full-time Ph.D. position for 4 years. The gross monthly salary increases from
€ 1877 in year 1 to € 2407 in year 4 in according to the Collective
Employment Agreement of the Dutch Universities. Terms of
employment for the Post-doc positions We offer a
temporary position initially for one year full time, with the possibility of
extension up to three years. The gross salary will be commensurate with
experience and performance and ranges from € 2639, - to € 3472, - per
month (salary scale 10 of the Collective Employment Agreement of the Dutch
Universities). For
both positions Secondary
benefits, based on the CAO Dutch Universities are excellent in general and
include e.g. a pension scheme, flexible employment conditions and salaries are
supplemented with a holiday bonus of 8% and a year-end bonus of 2% per year. How to apply? |
