*** For details on how to be removed from this list visit the *** *** CCP4 home page http://www.ccp4.ac.uk ***
Deal All, I'm posting this on behalf of prof Jerry Wells of UvA ([EMAIL PROTECTED]), please respond directly to him... Its protein expression mainly, but the project has a structure-based drive. Flip ---------------------------- Post-doctoral Research Scientist and Analyst to work on Antimicrobial Drug Discovery 3 year post-doctoral position and 1 year funding for an analyst -starting Jan 1, 2006 Background to the Project The acquisition of multi-drug resistance has rendered some hospital acquired infections and certain causes of community acquired pneumonia, meningitis and sepsis impossible to treat. Unless strategies for the development of alternative antibiotics are initiated soon, this will have an enormous social impact on the sustainability of other developments in modern medicine and quality of life worldwide. This Senter funded project involves two pharmaceutical companies and one other academic group with a combined aim of discovering new novel antibiotics against the relentless rise of infection caused by multi-drug (methicillin) resistant Staphylococcus aureus (MRSA), multi-drug resistant Streptococcus pneumoniae and vancomycin resistant Enterococcus (VRE). There are also clear possibilities to modify the drugs developed in this project to have activity against other kinds of drug resistant bacteria (e.g. see Current Opinion in Microbiology 2004, 7:439-444). Our strategy focuses on blocking the activities of an essential two-component regulatory system YycFG which is crucial for signaling in the disease target organisms (e.g. see Mohedano et al., J Bacteriol. 2005, vol 187:2357-67 & Stephenson et al., Current Opinion in pharmacology 2002, vol 2:1-6). The role of The University of Amsterdam in this project is to investigate the role of this two-component system and the mechanism of regulation in detail e.g. using DNA binding assays, quantitative PCR, regulatory mutants and genetic reporter systems. Additionally we will participate in determining the target protein structures and drug modeling through the expression of soluble proteins or protein domains and biochemical assay development. Further Information Ideally the post-doc will be a molecular biologist with previous experience of expressing and purifying proteins, microarray studies and of working with Gram-positive bacteria. Applications are also welcome from persons with basic knowledge in one or more of these areas who wish to develop new skills. The vacancies exist within the Cellular Microbiology Research Group headed by Prof. Jerry Wells This research group resides within the Swammerdam Institute for Life Sciences (SILS) the UVA Science Faculty's largest institute and shares excellent laboratory facilities and equipment with other microbiology groups working on topics such as gene regulation, fermentation, sporulation, host microbe interactions and systems biology. For further information on how to apply for these posts please contact [EMAIL PROTECTED] or visit the UVA job vacancies web site: http://www.english.uva.nl/news/uva_vacancies.cfm
