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Dear All, There has been a gratifying response to this release. Thanks to all who have tried it. The wide variety of systems and proteins tried has uncovered a number of minor but irritating problems. There are also hints that it has worked for some people but the extent is unclear - PLEASE give us positive feedback as well as problems ;-) Anyway, I don't want to clutter the BB with this, so can I ask users of Mr Bump to keep an eye on: http://www.ccp4.ac.uk/martyn/BMP/mrbump.php which we are keeping updated with known problems and fixes. Finally, if anyone is interested in getting email notifications, let me know. Cheers Ronan and Martyn On Thu, 5 Jan 2006, Martyn Winn wrote: > *** For details on how to be removed from this list visit the *** > *** CCP4 home page http://www.ccp4.ac.uk *** > > > > Dear All > > We are pleased to announced the release of a first version of > "Mr Bump" (formerly known as BMP), an automated scheme for Molecular > Replacement. Given a target sequence and experimental structure > factors, Mr Bump will search for homologous structures, create a set of > suitable search models from the template structures, do molecular > replacement, and test the solutions with some rounds of restrained > refinement. > > WHAT MR BUMP IS NOT: > It is not a new MR program - it uses Phaser and/or Molrep. > It is not particularly clever - it won't compete with an > expert crystallographer familiar with the target in question. > > WHAT MR BUMP WILL DO: > In straightforward cases, it will give you a positioned model > suitable for further refinement or re-building, with little > effort. > It will give results for a variety of templates and methods, > which may allow the discovery of an efficacious combination > that would have been missed by hand. > > Mr Bump can be downloaded from: > > http://www.ccp4.ac.uk/martyn/BMP/mrbump.php > > It comes complete with a ccp4i GUI and documentation. Information > on dependencies and installation can be found on this web page. > > Regards, > > Ronan Keegan > Martyn Winn > > > ************************************************************************** > * * > * Dr. Martyn Winn * > * * > * Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, ENGLAND * > * Tel: +44 1925 603455 E-mail: [EMAIL PROTECTED] (personal) * > * Fax: +44 1925 603825 E-mail: [EMAIL PROTECTED] (CCP4 problems) * > * URL: http://www.ccp4.ac.uk/martyn/martyn.html * > ************************************************************************** > > > ************************************************************************** * * * Dr. Martyn Winn * * * * Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, ENGLAND * * Tel: +44 1925 603455 E-mail: [EMAIL PROTECTED] (personal) * * Fax: +44 1925 603825 E-mail: [EMAIL PROTECTED] (CCP4 problems) * * URL: http://www.ccp4.ac.uk/martyn/martyn.html * **************************************************************************
