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Post-doctoral fellowship in the group of Dr. Stephen Cusack at EMBL Grenoble
Structural Studies of proteins involved in RNA maturation
A post-doctoral fellowship is available as soon as possible in the group
of Dr. Stephen Cusack at the EMBL Grenoble Outstation to work on
structural studies of proteins involved in RNA maturation in
eukaryotes.Previous work has led to the structure determination of a
protein sub-complex involved in 5’ processing of mRNA. The project will
continue with structure-based functional studies, the search for small
molecule inhibitors and structure determination of the full complex for
which preliminary crystals have been obtained. The successful candidate
will have technical expertise in molecular biology, protein expression
and purification, crystallization and protein crystallography and
ideally also in enzyme assays and /in vitro/ RNA transcription. A strong
motivation to work in the area of RNA metabolism is important.
The in-house research program of the EMBL Grenoble Outstation (
http://www.embl.fr <http://www.embl.fr/> ) focuses on the structural
molecular biology of complexes involved in eukaryotic cellular processes
This activity is supported by extensive technical platforms for
interdisciplinary structural biology run under the umbrella of the
Partnership for Structural Biology ( http://psb.esrf.fr/ ) together with
other on-site international (ESRF, ILL) and national (IBS, IVMS)
laboratories. These include high throughput protein expression and
crystallization, insect and mammalian cell culture, cryo-electron
microscopy, NMR and in particular, excellent access to the world-leading
synchrotron facilities of the ESRF.
Please send your CV and a covering letter of motivation with three
referees to Dr. S. Cusack, from whom additional information can be
obtained if required (telephone 0033-476207238, e-mail:
[EMAIL PROTECTED] <mailto:[EMAIL PROTECTED]>).
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Dr. Stephen Cusack,
Head of Grenoble Outstation of EMBL
Group leader in structural biology of protein-RNA complexes and viral proteins
Joint appointment in EMBL Gene Expression Programme
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Email: [EMAIL PROTECTED]
Website: http://www.embl-grenoble.fr
Tel: (33) 4 76 20 7238 Secretary (33) 4 76 20 7306
Fax: (33) 4 76 20 7786 or (33) 4 76 20 7199
Postal address: EMBL c/o ILL, BP181, 38042 Grenoble Cedex 9, France
Delivery address: EMBL c/o ILL, Polygone Scientifique,
6 Rue Jules Horowitz, 38042 Grenoble, France
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