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Hi all,
I have a docking problem, and would like to know if it is possible run a
free docking program with the following constraints. Any advice would be
grately appreciated.
I am trying to dock a heterodimer (65kDa and 75kDa) with a homodimer
(~35kDa). Since it is known that the homodimeric protein binds the the
heterodimeric protein, and that the heterodimeric protein shares a similar
domain in both subunits; it seems logical that similar regions of each
subunit of the homodimer bind to similar regions of the heterodimer.
Therefore, can I impose constrainsts that compare the two interdimer
interfaces, and score them on similarity.
Many thanks!
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