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Protein Crystallography PhD Studentship Applications are invited for BBSRC PhD studentships (3-yr) to start in October 2006. The award is available for UK candidates or resident EU. The ideal candidate should have a solid undergraduate background in molecular biology, protein biochemistry and/or biophysics. Structural biology of novel RNA binding proteins Novel protein GURB was recently identified as an RNA binding protein and a potential translational regulator of cell cycle controlling proteins in Xenopus oocytes by Cornelia de Moor's laboratory. The protein has turned up in several other proteomic studies that analysed RNP complexes, including in mRNA transport particles in neurons (de Hoog et al., 2004). GURB homologues have not been functionally charcterised in any species, but the protein is unusually well conserved (~50% identity) amongst animals and bacteria, including human and E. coli, suggesting an important role in cell physiology. GURB lacks any of the known RNA binding domains. The structural characterisation of GURB will lead to the description of a new RNA binding domain, defining a novel protein family. The work done on this project will contribute to the study of the function of GURB that is part of the Wellcome project currently active in Dr. de Moor's laboratory. Translational control is currently a very f! ast moving field, especially the translational control at synapses and in the cell cycle (Huang and Richter, 2004), and this work could bring a new dimension to it. This research area requires a multidisciplinary approach, and uses cell biological, biochemical techniques in conjunction with X-ray crystallography (http://www.nottingham.ac.uk/~pazxtal/). Phd students are provided with the opportunity to attend external training courses for developing skills in crystallographic methodology (usually hosted by the synchrotron organisation in Grenoble). Facilities available include a protein crystallization laboratory fully-equipped with X-ray data collection and crystallisation robot etc. yours jonas Dr Jonas Emsley Reader in Crystallography, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG72RD tel: 01158467092 fax:01158468002 email:[EMAIL PROTECTED] http://www.nottingham.ac.uk/~pazxtal/ http://www.nottingham.ac.uk/~pazweb2/lookup/roles/acad_admin/EmsleyJ.phtml This message has been checked for viruses but the contents of an attachment may still contain software viruses, which could damage your computer system: you are advised to perform your own checks. Email communications with the University of Nottingham may be monitored as permitted by UK legislation.
