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I was wondering about the possibility (futility?) of
working with a (potentially) rotationally disordered
data set.

Is it possible to use a disordered data set for
molecular replacement?  What would one look for in the
rotation and translation functions?

Is it possible to refine against rotationally
disordered data in protein data?

Is it possible, in principle, to generate
interpretable e-density maps from rotationally
disordered data for protein structures?


Steve

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