Q. Steven Xu wrote:
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Hi, everyone,
I am just wondering if anybody has experience on the molecular
replacement at very low resolution (say 20A or only 1000~2000
reflections). Was there any successful case at this resolution? or MR
has limitations on resolution (or the number of total reflections)?
Any reference?
Many thanks.
Steve Xu
LBL
It has been done, but at very low resolution your Xray data may more or
less reflect just the shape of the molecule and its packing in the unit
cell. If the molecule is roughly globular then you wont get much
distinction. If there is known NCS symmetry you can look for that and
match it up with that of the model - But it is hard to generalise.
Look at the EM/ Xray matching papers.. Usually the EM data ha an
effective resln of 10A or less.
Eleanor
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