Dear all,
I am trying to do my refinement together with my ligand using CNS. I used the HIC-up server to generate .top and .par files using the .pdb of my ligand. Surprisingly, the server returned those two files with a lot of the statements missing from the parameter files (such as nonbonded, IMPRoper, DIHEdral parameters). I managed to add nonbonded parameters manually but I don't know how I can add the rest of the statements into the file. I am wondering if there is anybody who had this problem before or is there anything that I did wrong along the way. Any advice will be really appreciated. Thank you very much!
Best,
Peng
