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Phil,
I am working on an almost identical problem at the moment - molecular
replacement with > 20% of the model missing. I've had great success
with Resolve - using the prime-and-switch protocol with solvent
flattening and averaging. Entire domains which were missing from the
MR solution are now clearly interpretable in the Resolve maps. I
also tried EDEN in this case, but the maps did not show the
additional domains.
All the best,
Megan
--
Dr Megan J Maher
Division of Molecular Biosciences
Imperial College London
South Kensington Campus
London SW7 2AZ
UK
Phone: +44 (0)20 7594 1900
FAX: +44 (0)20 7594 3022
Please note change of e.mail: [EMAIL PROTECTED]
