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The apparent Ki is a macroscopic parameter; the interpretation of it, whether a single binding event, or several, is microscopic. Multiple binding of a ligand or inhibitor is measured in the same way. On Sun, September 17, 2006 1:24 am, Michael nelson wrote: > Sorry,this is a non-ccp4 problem. > I have a inhibitor that is able to bind to multiple positions in a single > protein.Does anybody here know how to calculate or measure Kd or ki of > such a molecule. > Many thanks > Mike.
