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Deal all, I recently solved a structure at 1.7A by MAD. However, there is always strong negative density arround all 8 selenium in the protein during CNS refinement. The Selenium-methionines fit 2fo-fc density well. I tried to use peak, edge or remote dataset with or without scale anomalous flag on and all did not matter. Does anybody have a solution for this matter? Thanks. Zhen
