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Hi,
A post-doctoral position for structural studies related to
actin-cytoskeleton dynamic is available at the Laboratory of
Structural Enzymology and Biochemistry (LEBS), CNRS, Gif-sur-Yvette,
France, close to Paris. Starting date: February 2007. CNRS funding is
for three years. Annual gross salary: 25 800 euros.
Job description
The highly dynamic polymerization of ATP-actin is essential for a
variety of cellular processes, including formation of membrane
protrusions required for example for cell migration or endocytosis.
The research proposal explores the structural mechanisms supporting
motile processes by site-directed actin assembly and regulation of
actin cytoskeleton dynamic. These structural studies are pursued
within an internationally renowned group on actin cytoskeleton
dynamics in tight combination with dynamic analysis using biochemical
and biophysical methods
(<http://www.lebs.cnrs-gif.fr/carlier/carliereng.html>www.lebs.cnrs-gif.fr/carlier/carliereng.html).
We target the structure of actin in functional complexes with
actin-nucleators such as processive formins [Romero et al. (2004)
Cell. 119, 419-29] or with WASP-homology 2 (WH2) domain containing
proteins such as the G-actin-sequestering thymosin Beta4 [Hertzog M.
et al. (2004) Cell 117, 611-23]. First stable constructs are now
available for crystallization and biochemical studies and need to be
further extended.
The laboratory provides state-of-the-art equipment for protein
expression, purification and characterisations by biochemical and
biophysical methods. Crystallization robotics and X-ray diffraction
equipment are available in-house and we have regular access to
synchrotron sources.
Skills required
The successful candidate should have a strong experience in
molecular biology, protein expression and purification with basis in
biochemistry. Basic experience in crystallography would be an advantage.
Location
The laboratory is located in a very pleasant green setting within
the large CNRS campus of Gif-sur-Yvette which is 40 mn away from
Paris via local railway (RER B). We benefit from a dynamic scientific
surrounding, in close vicinity to both Orsay University, the Atomic
Energy Commissariat (CEA) center of Saclay and the SOLEIL synchrotron
(5 min away).
Contact:
Please send a CV, a short summary of your research experience and
letters of recommendation of two referees to Louis Renault
([EMAIL PROTECTED]). I will also be happy to provide further
information to interested candidates.
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Louis RENAULT
Laboratoire d'Enzymologie et Biochimie Structurales (LEBS)
Bat. 34, CNRS,
1, avenue de la Terrasse
91 198 Gif-sur-Yvette cedex, FRANCE
Phone: (+)33-1 69 82 34 89 (inside France: 01 69 82 34 89)
Fax: (+)33-1 69 82 31 29
email: [EMAIL PROTECTED]
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