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Dear ccp4bb readers, the University of Tromsø is now accepting applications for a challenging PhD position I previously announced here. The University Reference code for the application is 06/5419, and the application deadline is December 4, 2006. Applications must be submitted electronically at www.jobbnorge.no (or http://jobb.jobbnorge.no/visstilling2.aspx?stillid=34254〈=EN ), and also in paper form within the deadline. See additional details at http://uit.no/norstruct/3202/ . "The PhD-scholar will work with protein kinases that represent targets in anticancer drug design. The project aims to examine in detail the thermodynamics and structures of kinase—ligand interactions as a function of variations of the kinase sequence, domain architecture, post-translational modification, and ligand structure. The studies will identify determinants of kinase inhibition selectivity and also suitable model systems for practical drug design. The project studies involve bioinformatics analysis of kinase-ligand binding determinants, cloning and recombinant _expression_, biochemical and biophysical characterization by ITC and DSC calorimetry, spectroscopic methods including DLS and SPR, X-ray crystallography, and theoretical methods. Chemical synthesis and/or NMR methods are options as well." The PhD student is paid according to the Norwegian state salary scale 1017, approximately NOK 300000 per year. The University of Tromsoe is the world's northernmost university; Tromsoe and its surroundings offer a wide variety of opportunities in a spectacular setting with a perhaps surprisingly mild--and warming--climate. Use e.g. http://www.destinasjontromso.no/ or http://en.wikipedia.org/wiki/Tromsø as starting points for further information. Please forward this information to interested students. -Rick Engh -------------------------- Richard A. Engh Professor, Department of Chemistry The Norwegian Structural Biology Centre (Norstruct) Universitetet i Tromsø N-9037 Tromsø ------------------------------
