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I was shocked to see the retraction in yesterday's issue of Science (Dec 22, 2006) of several ABC transporter structures and papers from the Chang lab, including three published in Science. The retraction says that the structures have the wrong hand and topology due to an "in-house" program that inverted the signs on the anomalous pairs.
I have no expertise in ABC transporters, but were there warning signs in the structures? Were red flags raised by PDB or the other servers such as EDI, EDS, etc.? Looking at some of these papers, these are low resolution structure and I see very high R/Rfree, but there must have been other signs of problems as well.
In the past few years, there have been almost no structures retracted due to gross errors and the checks being used by structural biology community seemed to working quite well - what can we learn from this tragic and sad error ?
-- Arun Malhotra Phone: (305) 243-2826 Associate Professor Lab: (305) 243-2890 Dept. of Biochemistry & Molecular Biology Fax: (305) 243-3955 University of Miami School of Medicine PO Box 016129 E-Mail: [EMAIL PROTECTED] Miami, FL 33101 Web: http://structure.med.miami.edu
