Randy J. Read wrote:
On Jan 22 2007, Eaton Lattman wrote:
Will someone knowledgeable tell me what the present state of full 6
dimensional searches in molecular replacement?
...
If the latter, our feeling is that it isn't worth it. We've tried the
full search option on a couple of monoclinic problems (where it's only
a 5D search), and nothing came up with the full list of orientations
that didn't come up with the first hundred or so orientations. ...
As a related question, can anyone comment on the effects of symmetry on
MR (or direct me to appropriate literature)? Seems the rotation
function should give less information as the number of symmetry related
copies of the molecule in the unit cell goes up. Do people take into
account space group when deciding how many translation functions to
compute?
Thanks,
Jon
