There's also NMP (N-methyl-2-pyrrolidone). -- Ian
> -----Original Message----- > From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] On > Behalf Of Green, Todd > Sent: 22 January 2007 20:40 > To: [email protected] > Subject: [CCP4BB] crystal friendly solvents that are useful > for dissolving hydrophobic small molecules? > > Hello All, > > I am trying to soak some crystals with a small molecule that > is quite hydrophobic. I am having trouble with solubilty of > the small molecule. It will dissolve up to about 1 mM in 100 > % DMSO, but precipitates at concentrations of less than 15 > micromolar when the DMSO concentration is below 20 percent in > my crystal growth solutions(which are peg 4k, low pH, low > salt). Can anyone suggest solvents other than DMSO which > might help dissolve the inhibitor and might be somewhat > friendly to my crystals. > > Thanks in advance- > Todd Green > > Disclaimer This communication is confidential and may contain privileged information intended solely for the named addressee(s). It may not be used or disclosed except for the purpose for which it has been sent. If you are not the intended recipient you must not review, use, disclose, copy, distribute or take any action in reliance upon it. If you have received this communication in error, please notify Astex Therapeutics Ltd by emailing [EMAIL PROTECTED] and destroy all copies of the message and any attached documents. Astex Therapeutics Ltd monitors, controls and protects all its messaging traffic in compliance with its corporate email policy. The Company accepts no liability or responsibility for any onward transmission or use of emails and attachments having left the Astex Therapeutics domain. Unless expressly stated, opinions in this message are those of the individual sender and not of Astex Therapeutics Ltd. The recipient should check this email and any attachments for the presence of computer viruses. Astex Therapeutics Ltd accepts no liability for damage caused by any virus transmitted by this email. E-mail is susceptible to data corruption, interception, unauthorized amendment, and tampering, Astex Therapeutics Ltd only send and receive e-mails on the basis that the Company is not liable for any such alteration or any consequences thereof.
