The Institute of Cancer Research
Postdoctoral Training FellowS
Section of Structural Biology, Chelsea, London
The Institute of Cancer Research (a College of the University of
London) is a world-class cancer research organization with HEFCE RAE
ratings of international excellence across all of its research
programmes. In partnership with The Royal Marsden NHS Foundation
Trust, we form the largest comprehensive cancer centre in Europe,
dedicated to research that extends from epidemiology, genetics and
molecular biology, through drug discovery and development, to cancer
diagnosis and patient treatment. This makes us uniquely placed to
work towards our vision that people may live their lives free from
the fear of cancer as a life threatening disease.
The Section of Structural Biology has two Cancer Research UK funded
postdoctoral positions available for researchers holding PhDs (or
close to completing their PhD studies) in biochemistry, molecular
biology or structural biology. These positions are offered on fixed
term contracts of up to three years in the first instance with
starting salaries in the range £25,500 to £30,250 p.a. inclusive.
Mitotic Regulation & Cancer Team (CBL147)
The aim of the project is to investigate the activation mechanisms
of Aurora-A kinase, a key mitotic regulator that is essential for
proper mitotic spindle assembly and is overexpressed in many human
cancers. Aurora-A is activated by a number of proteins that share no
sequence or predicted structural homology, through different and in
some cases complementary mechanisms. The successful applicant will
address the question of how Aurora-A can be activated through
multiple mechanisms, using a combination of biochemical and
biophysical techniques including X-ray crystallography.
Chromatin Regulation Team (CBL148)
Dynamic changes in the packaging of chromatin have profound
implications for the regulation of eukaryotic transcription and DNA
repair mechanisms. The team is studying the structure and mechanism
of proteins and protein complexes responsible for the deposition and
recognition of regulatory marks in chromatin. The aim is to provide a
better understanding of epigenetic processes at the molecular level
with an emphasis on how impairment of the normal processes may
contribute to cancer. The post will provide an opportunity for the
development of a range of skills in biophysics and structural biology.
Experience in molecular biology, recombinant protein expression, and
purification with a structural biology / biophysics background will
be important.
Informal enquires may be made to Dr Richard Bayliss (Tel: +44 (0)20
7153 5557 / [EMAIL PROTECTED]) or Dr. Jon Wilson (Tel: +44
(0)20 7153 5122 / [EMAIL PROTECTED]). Please DO NOT send your
application to Drs. Bayliss or Wilson; CVs must be submitted in line
with the instructions below.
For further particulars and details of how to apply, please visit our
website at www.icr.ac.uk. Alternatively you may call our 24 hour
recruitment line on 020 7153 5475 quoting the relevant reference number.
Closing date: Fri 6th April
The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company
Limited by Guarantee, Registered in England under Company No. 534147 with its
Registered Office at 123 Old Brompton Road, London SW7 3RP.
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