Hi Sam Dogma would state that you are trying to maximise the correlation between your model and the structure, *without over fitting* and Rfree should thus be minimised.
However, you are likley using a maximum likelihood target, so you should maximise the likelihood so that the model accurately describes the data. (Refmac quotes likelihoods as -LLGs - so minimise this) HTH Dave On 25/04/07, U Sam <[EMAIL PROTECTED]> wrote:
Hi Everybody, I have small query. I am feeding ions and correcting few residues into my final structure. If R increases and Rfree decreases or vice versa in the subsequent refinement, which one I should accept and go forward. Thanks. Sam _________________________________________________________________ Discover the new Windows Vista http://search.msn.com/results.aspx?q=windows+vista&mkt=en-US&form=QBRE
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