Hi All, I have a question- kinda general though. I've always heard of stories from people that molecular replacement is often difficult in high symmetry space groups, like R32, cubic, etc... I'm not quite sure I understand why that is the case? Is the molecular replacement difficult because in high symmetry space groups you have so many molecules in the unit cell and therefore the patterson vectors becomes more complicated and therefore more difficult to find a match during cross rotation/translation? If this is the case, I'm wondering if this is still a problem with today's computers and software? Do people have a favorite molecular replacement program they like to use specifically in high symmetry space groups? or are there programs that don't handle high symmetry space groups very well? Do people have a preference between Amore, Phaser, MolRep, epmr, and CNS? Any anecdotes would be appreciated. Thanks in advance!
Jay
