Novartis Institutes of Biomedical Research in Basel, Switzerland are looking for a motivated individual to fill the role of a Research Investigator in protein crystallography.
The protein crystallographer will work in a biomolecular structure group dedicated to the production of structural data to support drug discovery programs in a wide variety of therapeutic indications. The job consists of the planning of gene-to-structure projects, the running of the crystallisation, data collection and structure determination efforts, and the presentation of the results obtained. Additional activities may include protein purification and studies of protein-ligand interactions using other biophysical methods (eg. ITC, DSC). The candidate will be expected to have an interest in fragment-based screening, exploring new ideas and implementing novel technologies. Good leadership and communication skills are essential as each research investigator has a role in coordinating the activities of a team to bring a drug target from given sequence to three-dimensional structure and to ensure the maximum impact of the structural work in the multidisciplinary drug discovery teams. The protein structure unit consists of experts in all areas from cloning to structural studies by X-ray and NMR. Specialist support in these areas is available as are state of the art equipment (well equipped purification labs, crystallisation and imaging robotics, Fr-E generator with sample changer and CCD and image plate detectors, and linux workstations with a large range of software) and excellent access to a synchrotron radiation source. Dedicated support for software and hardware is also available. Requirements: Education and training : PhD in structural biology, biochemistry, chemistry or related science Specific expertise : Protein X-ray crystallography, protein preparation, other biophysical techniques would be an advantage Necessary job experience : >1 years of postdoc studies, several years industrial experience including fragment-based screening would be an advantage General : Scientific and entrepreneurial initiative, team player, communication skills Languages : English a must, German desirable A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented, performance driven people. All of which makes us the most rewarding employer in our field. Applications for this position must be submitted via the Novartis Careers web page: www.novartis.com quoting position number 27952BR. Sandra Jacob Novartis Pharma AG DT/PSU: Unit head of Biomolecular Structure CHBS, WSJ-088.9.08A Novartis Pharma AG Forum 1 Novartis Campus CH-4056 Basel Switzerland Phone: +41 61 3249844 Fax: +41 61 3242686 Email : [EMAIL PROTECTED]
