Several Post-doctoral positions in structural biology are available at
the Structural Genomics Consortium, University of Toronto. The
Chromatin and Epigenetics Group at the Structural Genomics Consortium
(SGC), University of Toronto aims to characterize chromatin proteins
involved in histone code "reading" and "writing" by X-ray
crystallography in combination with other biochemical and biophysical
techniques, as part of the wider SGC effort on the human genome.
Research in the chromatin group is divided into three areas: 1)
Histone Code "Reading" Proteins: We are using peptide array, ITC and
differential static light scattering technologies to identify and
characterize novel histone modification binding proteins (Schuetz et
al, EMBOJ, 2006).2) Histone Code "Writing" Proteins: We are studying
the mechanism of histone modifying enzymes that regulate chromatin
structure and function such as histone deacetylases (Shuetz et al, Structure,
2007)), histone acetyltransferases (Shuetz et al, Proteins 2007) and
histone and DNA methyltransferases using structural, biochemical and
kinetic analysis to understand mechanisms of catalysis and inhibition.
3). Structure-Based Drug Discovery: Epigenetic abnormalities play an
important role in the pathogenesis of cancer and other genetic
diseases. Therefore, proteins involved in chromatin modifications are
attractive molecular targets for drug design. We are also
characterizing small molecules that can inhibit chromatin-regulating
proteins in collaboration with computational biologists.
Applicants should have a Ph.D. in structural biology, biochemistry,
biophysics, chemistry, or a related field with 0-3 years postdoctoral
research experience; prior training in X-ray crystallography is
desirable, but not required. Interested candidates are invited to
send their CV with 3 references to:[EMAIL PROTECTED] Structural
Genomics Consortium, University of Toronto, Canada.
____________________________________________________________________________________
Need a vacation? Get great deals
to amazing places on Yahoo! Travel.
http://travel.yahoo.com/
