It might be worth it to try phaser
Wu, Mousheng wrote: > hi, everyone! > > I am struggling with my crystal structure in a very big unit cell. my > protein is about 16KDa. probably there are about 20 molecules in the > asymmetric unit. I tried to use molecular replacement to solve the > structure. However, there is only one NMR structure available for me. The > second trouble is there are so many molecules in the ASU. I tried use NMR > structure as a model to solve it. MolRep gave me 4 solutions. I refined it > first and see the map. The map looks quite reasonable. some parts of the > model fit the density and some do not . i tried to trace one molecule > first. you can image how hard it is. > > Does anyone have such experience? how can i find so many solutions with > NMR model? your suggestions are much appreciated! > > Mousheng Wu >
