Engineer (fixed term contract for 2 years)
Responsible for setting up and developing a protein production and
crystallisation facility
Environment
The Structural Enzymology and Biochemistry Laboratory (LEBS) is part
of the Gif sur Yvette CNRS campus, 40mn from Paris by local train.
Using biochemistry, molecular biology, biophysics and X-ray
crystallography, the LEBS analyses fundamental mechanisms of protein-
protein and protein-RNA interactions that govern major cellular
functions, and applies its research to the discovery of molecules of
therapeutic interest. Most of our research work requires highly
purified and soluble protein in large quantities. A screening
facility for protein cloning, production and crystallisation is being
set up. Robotised equipment has already been purchased (pipetting and
visualisation robots; see http://www.lebs.cnrs-gif.fr/
plateau_technique.html). This facility will first be open to the
laboratory groups then to external users among which the local campus
laboratories and the nearby SOLEIL synchrotron.
Job description
Under the supervision of a research engineer and in collaboration
with users from the LEBS, he/she will setup the facility. His/her
mission will be
- design and validation of standardised protocols for the
protein cloning and production station
- design and validation of improved protocols for the
crystallisation robots
- setup the facility in the Laboratory
- define and apply quality criteria
Skills required
The qualified individual will have a B.S./M.S. in biological science
and must be a team player with good communication skills.
- experience in molecular biology and protein biochemistry is
required
- experience with protein crystallisation desirable
- knowledge of robotics applied to biotechnology a plus
Deadline for application: September 15 2007.
You will find more information about the laboratory and its
environment at http://www.lebs.cnrs-gif.fr
To apply or obtain additional information about the position, please
contact Dr Jacqueline Cherfils
[EMAIL PROTECTED]
Laboratoire d’Enzymologie et Biochimie Structurales, CNRS
Avenue de la Terrasse
91198 Gif-sur-Yvette Cedex France
