I have read the comments in Nature and on the CCP4BB with excitement, almost the same level of excitement with which I followed this year's Tour de France. Speaking of which, I can see many analogies.

Political correctness aside, what is the meaning of an (internationally acclaimed) journal if people cannot point out flaws in publicly available scientific models, whether published in Nature or any other journal? We can go to great length in making all crystallographic data freely and publicly available but that doesn’t change the problem with commercial journals as mentioned by Rupp. Mind you, I have never been in the luxury position to contemplate submission to Nature, so maybe I should stick with Robert Huber’s credo. It is not the credibility of crystallography that is at stake, but the credibility of the big journals, as phrased by Jones and Kleywegt.

Also, I am not interested in 'public excoriation' at all. I am fussed about a clean database (PDB) and letters in journals that truly reflect the opinion of scientists all over the world. It is embarassing to see that accepting the comment by Jansen et al took 6 months, while accepting the original papers containing a lot more experimental data to judge took just over a month.

There was a recent debate about anonymous refereeing. Here is something else to consider: whenever a paper contains a crystal structure it should be refereed by at least one crystallographer (Bernard Rupp’s pairing scheme). If this were to be a crystallographer working on proteins/subjects unrelated to those in the paper, then there is less need for the crystallographer to remain anonymous and this might help a great deal in persuading authors to send off their raw data in confidence.

Carien


Dr. Carien Dekker
Dept. Cell & Molecular Biology
Institute of Cancer Research
Chester Beatty Laboratories
237 Fulham Road
London, SW3 6JB

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