Two postdoctoral positions are available immediately to study structure-function relationships of integral membrane proteins. One position (funded by NIH) will focus on the transport mechanism of hydrophobic compounds across the bacterial outer membrane as mediated by FadL-family proteins. The second position (funded by a PEW scholar grant) concerns prokaryotic and eukaryotic divalent metal transporters belonging to the ZIP (Zrt/IRT-like protein) family. Work will involve overexpression and purification of membrane proteins in E. coli and Pichia pastoris, membrane protein crystallization and structure determination, and development of in vitro substrate binding and transport assays. Applicants should have a strong background in molecular biology and protein chemistry. Experience in membrane protein purification and X-ray crystallography would be desirable, but is not required. Interested and highly motivated candidates should state their project of interest and e-mail their CV and the contact details of three references to:
Bert van den Berg e-mail: [EMAIL PROTECTED] University of Massachusetts Medical School Program in Molecular Medicine Biotech II, 373 Plantation Street, Suite 115 Worcester MA 01605 Phone: 508 856 1201 (office); 508 856 1211 (lab) http://www.umassmed.edu/pmm/faculty/vandenberg.cfm
