Warren,
Quite a beauty... what a nice way to show the effect of the
mutation in the binding site.
really nice,
Mario
Warren DeLano wrote:
http://delsci.com/morph
It's a start...
-----Original Message-----
From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] On Behalf Of
Gerard DVD Kleywegt
Sent: Wednesday, October 03, 2007 6:55 AM
To: [email protected]
Subject: Re: [ccp4bb] Morphing with mutations
What about to do a cartesian morphing with the mutated
residue
added (or removed) atoms having initial ( or final) coordinates taken
from
previous common atom?
Will work? Coloring may be a factor... but with a manual
editing
perhaps...
you mean, for instance, if you have an Ala->Trp you call the ala 'trp',
add
all missing 'trp' side-chain atoms and put them on top of the CB, and
then
morph to the real trp, so the additional side-chain atoms will slowly
"explode" out of the CB and towards their final positions? (and for a
Trp->Ala
mutation you could do the same thing of course, but the extra side-chain
atoms
would then be "sucked up" by the CB like a black hole) yep, that is a
trick
that would probably work!
if anyone gets it to work, i would be interested in seeing the result
and
learning details, so i could add it to the lsqman manual or the morphing
tutorial
--dvd
******************************************************************
Gerard J. Kleywegt
[Research Fellow of the Royal Swedish Academy of Sciences]
Dept. of Cell & Molecular Biology University of Uppsala
Biomedical Centre Box 596
SE-751 24 Uppsala SWEDEN
http://xray.bmc.uu.se/gerard/ mailto:[EMAIL PROTECTED]
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The opinions in this message are fictional. Any similarity
to actual opinions, living or dead, is purely coincidental.
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