Hi all
I have searched the PDB without much luck and wondered whether anyone out there
could confirm:
I'm looking for co-crystal structures of enzymes with inhibitors that bind to
the catalytic group via a ketone moiety. Our case is a metalloprotease with a
ketomethylene peptide analogue but any kind will do.
As far as I can tell, the PDB has a few examples with an aldehyde at one of the
termini of the inhibitor (e.g. 1LAN, 1CBX), and some with modified ketones (e.g
fluoro-, 1OD1, 1NJS) but none with an unmodified internal ketone.
So far, I've found some carboxypeptidase A papers from the 80's and nothing
since. Have I missed something?
Sincerely
Jean Watermeyer
Jean Watermeyer
Division of Medical Biochemistry
IIDMM
University of Cape Town Health Sciences
Anzio Rd Observatory
7925
South Africa
Tel. 021 4066832
PLEASE UPDATE: my email address has changed: [EMAIL PROTECTED]
Jean Watermeyer
Division of Medical Biochemistry
IIDMM
University of Cape Town Health Sciences
Anzio Rd Observatory
7925
South Africa
Tel. 021 4066832
