STRUCTURAL BIOCHEMISTRY OF THE INTERACTION OF KINESINS WITH TUBULIN
A post-doctoral fellowship is available at the Laboratoire d'Enzymologie et Biochimie Structurales (LEBS), CNRS, Gif-sur-Yvette, France. The contract will be initially for a period of one year. Our group works on the structural study of the regulation of microtubule assembly. This project deals with kinesins that catalyse microtubule disassembly. In this project, we will study the interaction of these kinesisns with tubulin by biophysical and biochemical methods in solution and characterize the resulting complexes by X-ray crystallography and in collaboration with electron microscopists. The lab has state of the art equipment for protein purification and characterization. Crystallization robotics and X-ray diffraction equipment are also available in-house (see http://www.lebs.cnrs-gif.fr/home.html). We are located in a multidisciplinary life sciences campus, 40 minutes by direct train from the centre of Paris with a regular access to synchrotron sources including the closeby french synchrotron SOLEIL. Applicants should hold a Ph. D., have experience in biochemistry (cloning, protein expression, purification and characterization) and an interest in structural studies. Experience in protein crystallization and crystallography would be an advantage but motivated biochemists – molecular biologists will be trained in these techniques. To apply, please send a CV, a short summary of your research experience and the names and contact information of two referees by e-mail to Dr. Marcel Knossow ([EMAIL PROTECTED]). For details on the group please see our web page (http://www.lebs.cnrs-gif.fr/knossow/knossowang.html).
