POSTDOCTORAL RESEARCH ASSOCIATE -
Project Title: Novel Methods for Microcrystal Structure Determination at NSLS and NSLS-II
Location: Brookhaven National Laboratory, Upton, NY, U.S.A.
This new project is under the direction of A. M. Orville, and is also associated with the PXRR group (www.px.nsls.bnl.gov) at Brookhaven National Laboratory (BNL). The PXRR group conducts research, technology development, operations, and training at six beamlines (X8, X12b, X12c, X25, X26c, X29) at the National Synchrotron Light Source (NSLS). A long-term goal for the PXRR group is to create a resource for macromolecular crystallography at NSLS-II, the new synchrotron light source that is being created at BNL during the next five to seven years.
Microcrystals only a few microns along an edge are often easy to obtain; but, are typically of no use for traditional diffraction studies. In contrast, the brightness and focused beam anticipated at NSLS-II provides an ideal opportunity to use microcrystals for diffraction studies. A major barrier that remains to be overcome is how to manipulate microcrystals for structure determination. Part of the research strategy will be to use a large number of randomly oriented microcrystals, from each of which only a small fraction of the whole dataset is collected, in order to build-up the complete dataset. Full _expression_ of these methods may approach the physical limits of crystal diffraction and will clearly help motivate the optimum performance of NSLS-II. Consequently, we will develop novel microcrystallography methods at the NSLS and look forward to utilizing the outstanding characteristics of NSLS-II facility.
The position requires a Ph.D. in biochemistry, structural biology, chemistry, or physics. Experience in macromolecular crystallography and/or synchrotron x-ray sources is desired. The prospective candidate must be able to interact with a diverse group of scientists and engineers, as well as work independently. Send CV and contact information for four mentors or referees to [EMAIL PROTECTED] referring to Position No. FH4835.
AMO
Allen M. Orville, Ph.D.
Biology Department
Brookhaven National Laboratory
Upton, NY 11973-5000
e-mail: [EMAIL PROTECTED]
phone 631-344-4739
fax 631-344-2741
www.biology.bnl.gov/structure/orville.html
