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Hi,
I had a very curious result when doing a round of isotropic B factor
refinement on Refmac5.
After iso B my R is 19.2 and Rf 24.3. My resolution is 1.95, what does
not justify anisotropic b-factor refinement. However I did it by mistake
and it dropped my R to 17.8 and Rf to 23.5. More curiously, I next did a
B iso refinement round and my R dropped to 16.1 and Rf to 21.8!
Would you have any insights why my second round of iso B refinement
dropped my Rs considerably after the aniso B refinement?
Thank you very much,
Rafael.
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