Job PhD position
Institution Institute of Biophysics and Nanosystems Research
Austrian Academy of Sciences, Graz
Topic Molecular structure of apolipoproteins
Duration 3 years
Salary According to the salary schemes of the
Austrian FWF
Starting date March 2008
Contact Univ.Doz.Dr. Ruth Prassl
([EMAIL PROTECTED])
Project summary
The aim of this project is to explore the three dimensional domain
structure of lipid-free apolipoprotein B100 (apo-B100), which is the
only protein moiety of the primary human cholesterol carrier low density
lipoprotein (LDL), and of defined fragments thereof, as well as of avian
apo-VLDL-II, which is the most effective endogeneous inhibitor of the
important enzyme lipoprotein lipase known.
Detailed information on www.fwf.ac.at project-database /project number
P20455.
Job description
We are looking for a highly motivated student to meet the challenge to
solve the structure of human apolipoproteins and to tackle a demanding
but fascinating topic. Focus of work is on protein purification,
biophysical characterisation, crystallisation, low resolution structure
determination by small angle X-ray scattering and X-ray protein
crystallography.
Requirements
The candidate must hold a MSc degree and should have a sound background
in biochemistry, laboratory experience, computer skills and should be
conversant with concepts of lipoproteins and/or lipid membranes.
