Jon, I have not had any replies. I did hear a talk at an American Chemical Society meeting on a ligand flipping between the two estrogen receptor subtypes, but it hasn¹t been published from what I can tell. Here¹s a link to the abstract.
membership.acs.org/C/COMP/pastprograms/Fall06abstracts.pdf Kendall On 2/18/08 8:38 PM, "Read, Jon" <[EMAIL PROTECTED]> wrote: > Hi Kendall, > did you get any replies about this as I would be interested in hearing about > these. I have seen some talks of kinases which mention this but can't recall > the targets. >> >> -----Original Message----- >> From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] Behalf Of Kendall >> Nettles >> Sent: Saturday, February 09, 2008 11:04 AM >> To: [email protected] >> Subject: [ccp4bb] References for ligand flipping >> >> >> >> Hi, >> Thanks to everyone for suggestions on making disulfides. I do have another >> question. >> >> Can anyone suggest some references for structures showing that a small >> molecule ligand binds differently in closely related proteins? >> >> >> Thanks, >> Kendall >> -- >> Kendall W. Nettles, PhD >> Assistant Professor >> Department of Cancer Biology >> The Scripps Research Institute >> 5353 Parkside Dr. >> Jupiter Fl 33458 >> >
