The Institute of Cancer Research (University of London) Cancer Research UK Centre for Cell and Molecular Biology & Section of Structural Biology
Chester Beatty Laboratories - Chelsea, London Post-doctoral Training Fellow Structure and Interactions of the Retinoblastoma-associated Protein Applications are invited for a Post-doctoral position funded by Cancer Research UK, to work on structure and interactions of domains of the retinoblastoma-associated protein pRb, implicated in regulation of DNA replication and apoptosis (see Hassler et al, 2007, Mol. Cell, 28, 371-385). The project is a collaboration between the teams led by Dr. Sibylle Mittnacht (Cancer Research UK Programme on tumour cell signalling networks) and Prof. Laurence Pearl (Structural Biology) at the Chester Beatty Laboratories. Between them these teams share an extensive range of state of the art equipment for biochemical, biophysical and structural work. The laboratories are exceptionally well equipped for all aspects of modern cell biology and structural biology, with state-of-the-art equipment for cell imaging, mass spectrometry, X-ray crystallography and structural electron micoscopy. Applicants should hold a PhD in Macromolecular Crystallography or Protein biochemistry with postdoctoral experience in recombinant expression, protein purification and, ideally, crystallographic structure determination. Protein biochemistry, protein crystallisation and computational crystallography skills are essential and candidates with a working knowledge of eukaryotic cell biology, cell-cycle control, DNA replication survival and apoptosis will be at an advantage. The Institute of Cancer Research (a College of the University of London) is a world-class cancer research organization with HEFCE RAE ratings of international excellence across all of its research programmes. In partnership with The Royal Marsden NHS Foundation Trust, we form the largest comprehensive cancer centre in Europe, dedicated to research that extends from epidemiology, genetics and molecular biology, through drug discovery and development, to cancer diagnosis and patient treatment. This makes us uniquely placed to work towards our vision that people may live their lives free from the fear of cancer as a life threatening disease. The post is offered on a fixed-term contract with a starting salary in the range £29,256 to £36,922 p.a. inclusive based on relevant skills and experience. Informal enquiries to Dr Sibylle Mittnacht ([EMAIL PROTECTED]) or Prof. Laurence Pearl ([EMAIL PROTECTED]) are encouraged but DO NOT send your application to this email address. Please submit applications along with names of two references quoting reference number C125. For further particulars and details of how to apply, please visit our website at www.icr.ac.uk Alternatively you may call our 24 hour recruitment line on 020 7153 5475 quoting reference number C125. Closing date: 31st March 2008 -------------------------------------------------------------------------------- Laurence H. Pearl PhD FMedSci Professor of Protein Crystallography and Section Chairman Section of Structural Biology, Institute of Cancer Research Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK Phone +44-(0)20 7153 5422 : Secretary +44-(0)20 7153 5443 : FAX +44-(0)20 7153 5457 -------------------------------------------------------------------------------- "Live Simply and do Serious Things .. " - Dorothy Crowfoot Hodgkin -------------------------------------------------------------------------------- The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
