POSTDOCTORAL POSITION AVAILABLE A postdoc position is available at Case Western Reserve University in the structural biology lab of Dr. Focco van den Akker. The project is funded by NIH and involves structure-function studies of cyclic nucleotide signaling pathways. These pathways are involved in processes such as regulation of blood pressure and bone growth; a number of proteins in this pathway are drug targets for treating hypertension and congestive heart failure. One of the classes of proteins we are targeting for structure-function studies are guanylyl cyclases (Ma et al., EMBO J, 26, p578-; Ma et al., JBC, 283, p1167-; Sayed et al., PNAS, 104, p12312-; van den Akker et al., Nature 406, p101-). See website for details: http://daspot.bioc.cwru.edu/Focco/project1.html
Other proteins in this pathway are targeted as well in collaboration with a number of academic and pharmaceutical partners. The goal of this project is to delineate the molecular signaling events of these pathways using a multi-disciplinary approach with an emphasis on crystallography, and to exploit these insights for therapeutic modulation. Access to state-of-the-art equipment and facilities are available including a newly-installed Rigaku Micromax-007 ccd diffraction system. Applications will be accepted from highly motivated individuals who have recently obtained their Ph.D. (less than 4 years). The applicant should have experience in either molecular biology or protein biochemistry (experience in protein crystallography is not required but is desirable). The position is open immediately and salary will be commensurate with qualifications and experience. Please send cover letter, CV, and list of 3 references to: [EMAIL PROTECTED] Focco van den Akker, Ph.D. Assistant Professor Department of Biochemistry/RT500 Case Western Reserve University 10900 Euclid Avenue Cleveland, OH 44106 Website: http://daspot.bioc.cwru.edu/Focco/ The Case Western Reserve University is an Equal Opportunity/Affirmative Action employer.
