Dear Sean --

Is there a way to search the PDB for both sequence and secondary structure characteristics? I am trying to identify examples of a short (4 aa) sequence located in loop or other non-helical/sheet regions.

you can try the PRINTS database:

http://www.bioinf.manchester.ac.uk/dbbrowser/PRINTS/QuizPRINTSSQ.html

Not sure you'll get what you want with 4 aa, but it can still be of use.

HTH

Kind regards.

Leo
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Chavas Leonard, Ph.D.
Research Associate
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Faculty of Life Sciences
The University of Manchester
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