Dear Jim, The funny part is that the same journals will publish NMR structures. In terms of data/parameter ratio or in terms of comparing quality (Battacharya, Tejero and Montelione, Proteins:structure function genetics 66:778-795), the good NMR structures are about 2.5A resolution and most NMR structures are around 3.5A resolution.
I do not think the resolution is the problem, I think poor review is the problem. There are X-ray structures to 2.5A resolution that are worse than those at 3.5A resolution in the PDB..... Rams. > Dear Jim, > > I guess you entered the ABC transporter zone. > > You say you use the structure to show the movement of helices. > One important point is whether this structure is based on a > molecular replacement solution, or it was built from experimental > phases. There are numerous cases where adding some experimental > phasing helped to convince the editors. > > Good luck, > > Rob Meijers > Synchrotron Soleil > > Jim Naismith <[EMAIL PROTECTED]> wrote: Dear All, > I have an interesting problem, we have a 3.45A structure of > a membrane protein. We have just been told that the structure is "too low > resolution to be considered as the uncertainty is too high". We use the > structure to identify helices which have moved. > > Is there a blanket ban on low res structure operating at the moment? > > The structure was refined extremely tightly, MolPROB 98th centile. (I will > happily send the data and structure to anyone who wishes to validate.) The > editors simply ignored everything but the res limit (I/sI in the last > shell > was 1.8 with a redundancy of 4) > > Of course we will begin the usual journal shopping. However, does anyone > know how to convince editors and non-xtallographers that 3.45A is valid? > > Best > Jim > > > James H. Naismith FRSE |Research mailto:[EMAIL PROTECTED] > Professor of Chemical Biology |Teaching mailto:[EMAIL PROTECTED] > Centre for Biomolecular Sciences |Office: 1334-463792 > The North Haugh |Fax : 1334-467229 > The University |Lab : 1334-467245 > St. Andrews |In UK add 0 to start of number > Fife Scotland, U.K., KY16 9ST |http://www.st-and.ac.uk/~strucbio > > The University of St Andrews is a charity registered in Scotland : No > SC013532 > > > __________________________________________________ > Do You Yahoo!? > Tired of spam? Yahoo! Mail has the best spam protection around > http://mail.yahoo.com
