A post-doctoral position and a technician position available in the Netherlands Cancer Institute in the groups of Titia Sixma. The Netherlands Cancer Institute is a center of excellence with a high standard of biological research and an interactive atmosphere. It is located in Amsterdam, with all its cultural amenities, close to Schiphol airport.
The group has an interest in structural studies coupled to functional analysis. We share meetings and lab-space with the group of Tassos Perrakis, who amongst other things has an interest in method development for structural biology. Equipment includes expression in mammalian and insect cells, high throughput crystallization, in-house X-ray facility (MarDTB with Bruker optics), surface plasmon resonance (Biacore), isothermal titration calorimetry, static light scattering (MALLS), mass spectrometry etc. The project focuses on the ligand binding process in cys-loop receptors. We study these pentameric ion-channels, for which the nicotinic acetylcholine receptor is the prototype, primarily through structure-function analysis on the model protein AChBP. Using a combination of biophysical analysis and protein crystallography and we collaborate closely with neurobiologists (Guus Smit, VU, Amsterdam), chemists interested in drug design (e.g. de Esch, VU) and electrophysiologists (Bertrand, Geneva) as well as other members of the EU-network Neurocypres. We are looking for enthusiastic researchers with experience in protein crystallography, molecular biology and/or biochemistry. Applicants should write an e-mail with CV and names of three references to [EMAIL PROTECTED] Titia Sixma Prof. Titia K. Sixma, Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam,The Netherlands Phone: +31-20-5121959/50, Fax: +31-20-5121954, E-mail: [EMAIL PROTECTED] , Website: http://xtal.nki.nl
