Dear All : I am studying a mutant protein related with a disease. In the mutated version of this protein there is an alpha helical segment that protrudes into the solvent. This alpha helix is not present in the wild type protein.
I was wondering if any of you know some papers in which the "toxicity" of this exposed hydrophobic alpha helices is reported. I have some cross-references in which the authors said that some of these exposed hydrophobic alpha helical fragments could recrute cellular chaperones (Hsp70 and Hsp90). Any help will be appreciated All the best Francisco -- ----------------------------------------- Francisco J. Enguita, Ph.D. Host-pathogen Interactions Group Macromolecular Crystallography Laboratory ITQB EAN, Av. da República 2781-901 Oeiras Portugal Phone : +351-21-4469663 Fax : +351-21-4433644 E-mail : [EMAIL PROTECTED] -----------------------------------------
