Dear Friends and scientists, I know An inhibitor(Say A) that acts as an anti destabilizing agent for a homotetrameric protein. that is the disturbance in the tetramer leads to aggregation of the protein ,this inhibitor A stabilizes this disturbance....this is one story.
the other, recently we were involved in investigation the inhibitory affect of the same inhibitor A for another protein, and found some density(may be ..)between the interface of the protein molecules(homodimer). is there any way out there to compare the protein -protein interfaces of two different protein.ie to get information about the volume occupied by ligand and the residues it is interacting with ie i want to superpose the interface of two different proteins and compare the situation. S.Jayashankar Research Student Institute for Biophysical Chemistry Hannover Medical School Germany
